The surface functionalization of nanoparticles is a key step for their application and the control of colloidal stability. At the interface between the particles and the solvent, the grafting of specific organic molecules is often a complex operation. Complex for the realization of the attachment on the nanometric solid, complex for the purifications and finally for the characterizations too.
The company has developed exceptional expertise in hybrid nanomaterials. For more than 15 years, the teams have been involved in the Nano-Hybrids colloquium focused on this issue.
Nano-h is specialized in direct or indirect surface grafting, functionalization using polysiloxane, and functionalization of metallic nanoparticles (in particular nano-gold).
The control of the grafting steps is particularly monitored thanks to our granulo-zetameters (photo) and HPLC equipment, in particular HPLC-ICPMS for inorganic hybrid nanoparticles.
Nano-H equipment for nanoparticle functionalization :
Clic on the images to check the reference
Some Nano-H publications of nanoparticle functionalization :
V. Thakare, V. –L. Tran, M. Natuzzi, E. Thomas, M. Moreau, A. Romieu, B. Collin, A. Courteau, J.-M. Vrigneaud, C. Louis, S. Roux, F. Boschetti, O. Tillement, F. Lux, F. Denat, « Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging », RSC Advances, 2019, 9, 24811-24815.
V. L. Tran, V. Thakare, M. Natuzzi, M. Moreau, A. Oudot, J. –M. Vrigneaud, A. Courteau, C. Louis, S. Roux, F. Boschetti, F. Denat, O. Tillement, F. Lux*, « Functionalization of gadolinium chelates silica nanoparticle through silane chemistry for simultaneous MRI/64Cu PET imaging », Contrast Media Mol. Imaging, 2018, 2018:7938267.
Plissonneau, M.; Pansieri, J.; Heinrich-Balard, L.; Morfin, J.-F.; Stransky-Heilkron, N.; Rivory, P.; Mowat, P.; Dumoulin, M.; Cohen, R.; Allemann, E.; et al. Gd-Nanoparticles Functionalization with Specific Peptides for Beta-Amyloid Plaques Targeting. JOURNAL OF NANOBIOTECHNOLOGY 2016, 14.
Miot-Noirault, E.; Vidal, A.; Morlieras, J.; Bonazza, P.; Auzeloux, P.; Besse, S.; Dauplat, M.-M.; Peyrode, C.; Degoul, F.; Billotey, C.; et al. Small Rigid Platforms Functionalization with Quaternary Ammonium: Targeting Extracellular Matrix of Chondrosarcoma. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2014, 10, 1887–1895.