Particle Development
At Nano-H, we specialize in developing high-performance hybrid nanoparticles with scalable production capabilities, from milligrams to kilograms. Through advanced synthesis, functionalization, and purification, we deliver custom inorganic particles with rigorous quality control, tailored for applications in optics, medical imaging, diagnostics, and pharmaceuticals.
Synthesis
Functionalization
Characterization
Purification
Synthesis
From mg to kg, Nano-H offers a wide range of synthesis reactors and devices allowing the production of customized batches of nanomaterials.
The synthesis equipment is complemented by freeze-drying and sterilization equipment allowing the realization of specific batches.
Specialized in inorganic particles, metals, oxides, halides; the company has a very large experience in lanthanide-based particles for almost 20 years.
Nano-H synthesis equipment :
Some Nano-H synthesis publications
-
V. –L. Tran, V. Thakare, F. Rossetti, A. Baudouin, G. Ramniceanu, B. –T. Doan, N. Mignet, C. Comby-Zerbino, R. Antoine, P. Dugourd, F. Boschetti, F. Denat, C. Louis, S. Roux, T. Doussineau, O. Tillement, F. Lux*, « One-pot direct synthesis for multifunctional hybrid silica nanoparticles », J. Mat. Chem. B, 2018, 6, 4821-4834.
-
Ou, M.; Mutelet, B.; Martini, M.; Bazzi, R.; Roux, S.; Ledoux, G.; Tillement, O.; Perriat, P. Optimization of the Synthesis of Nanostructured Tb3+-Doped Gd2O3 by in-Situ Luminescence Following up. JOURNAL OF COLLOID AND INTERFACE SCIENCE 2009, 333, 684–689.
-
Mouzon, J.; Dujardin, C.; Tillement, O.; Oden, M. Synthesis and Optical Properties of Yb0.6Y1.4O3 Transparent Ceramics. JOURNAL OF ALLOYS AND COMPOUNDS 2008, 464, 407–411.
Functionalization
From mg to kg, Nano-H offers a wide range of synthesis reactors and devices allowing the production of customized batches of nanomaterials.
The synthesis equipment is complemented by freeze-drying and sterilization equipment allowing the realization of specific batches.
Specialized in inorganic particles, metals, oxides, halides; the company has a very large experience in lanthanide-based particles for almost 20 years.
Nano-H functionalization equipment :
Some Nano-H functionalization publications
-
V. Thakare, V. –L. Tran, M. Natuzzi, E. Thomas, M. Moreau, A. Romieu, B. Collin, A. Courteau, J.-M. Vrigneaud, C. Louis, S. Roux, F. Boschetti, O. Tillement, F. Lux, F. Denat, « Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging », RSC Advances, 2019, 9, 24811-24815.
-
V. L. Tran, V. Thakare, M. Natuzzi, M. Moreau, A. Oudot, J. –M. Vrigneaud, A. Courteau, C. Louis, S. Roux, F. Boschetti, F. Denat, O. Tillement, F. Lux*, « Functionalization of gadolinium chelates silica nanoparticle through silane chemistry for simultaneous MRI/64Cu PET imaging », Contrast Media Mol. Imaging, 2018, 2018:7938267.
-
Plissonneau, M.; Pansieri, J.; Heinrich-Balard, L.; Morfin, J.-F.; Stransky-Heilkron, N.; Rivory, P.; Mowat, P.; Dumoulin, M.; Cohen, R.; Allemann, E.; et al. Gd-Nanoparticles Functionalization with Specific Peptides for Beta-Amyloid Plaques Targeting. JOURNAL OF NANOBIOTECHNOLOGY 2016, 14.
-
Miot-Noirault, E.; Vidal, A.; Morlieras, J.; Bonazza, P.; Auzeloux, P.; Besse, S.; Dauplat, M.-M.; Peyrode, C.; Degoul, F.; Billotey, C.; et al. Small Rigid Platforms Functionalization with Quaternary Ammonium: Targeting Extracellular Matrix of Chondrosarcoma. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2014, 10, 1887–1895.
Characterization
Thanks to a historical partnership with the team of Pr. O. Tillement, we propose a complete equipment allowing the characterization of nanopraticles and their properties, with in particular : granulometry - zetameters - HPLC (UV - dn - fluo) - HPLC-ICP/MS ICPMS - Spectrofluorometers - Relaxometers
Nano-H characterization equipment :
Some Nano-H characterization publications
-
A. Conti, R. Magnin, M. Gerstenmayer, N. Tsapis, E. Dumont, O. Tillement, F. Lux, D. Le Bihan, S. Mériaux, S. Della Penna, B. Larrat, « Empirical and theoritical characterization of the diffusion process of different gadolinium-based nanoparticles within the brain tissue after ultrasound-induced permeabilization of the blood-brain barrier », Contrast Media Mol. Imaging, 2019, 2019:6341545.
-
S. Huclier-Markai, E. Ntsiba, E. Thomas, C. Aliot, C. S. Cutler, F. Lux, O. Tillement, « Self-crosslinked fibrous collagen/chitosan blends: Processing, properties evaluation and monitoring of degradation by bi-fluorescence imaging », Multimodal AGuIX® nanoparticles: size characterization by HF5 and optimization of the radiolabeling with various SPECT/PET/Theranostic tracers », Int. J. Med. Nano Res., 2019, 6, 027
-
Truillet, C.; Thomas, E.; Lux, F.; Huynh, L. T.; Tillement, O.; Evans, M. J. Synthesis and Characterization of Zr-89-Labeled Ultrasmall Nanoparticles. MOLECULAR PHARMACEUTICS 2016, 13, 2596–2601.
-
Ricciardi, L.; Martini, M.; Tillement, O.; Sancey, L.; Perriat, P.; Ghedini, M.; Szerb, E. I.; Yadav, Y. J.; La Deda, M. Multifunctional Material Based on Ionic Transition Metal Complexes and Gold-Silica Nanoparticles: Synthesis and Photophysical Characterization for Application in Imaging and Therapy. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 2014, 140, 396–404.
Purification
The purification of nanoparticles is a fundamental step in the development of nanomaterials and nanomedicine.In addition to conventional processes, crossflow filtration is unquestionably the technique of choice for ultrafine particles of a few tens of nanometers or even smaller.With more than ten years of experience in the purification of tracers, nanomedicine or simply in fundamental, our teams provide devices allowing the purification of colloidal solutions on more than 4 orders of magnitude: from less than 0.1 mL to 20 L. The membrane used allows extraction cuts from 1 kDa to more than 100 kDa.
Nano-H purification equipment :